Sialic acid-binding Ig-like lectin 8 (Siglec-8) (Sialoadhesin family member 2) (SAF-2)
1_MLLLL 6_ LLLPL 11_ LWGTK 16_ GMEGD 21_ RQYGD 26_ GYLLQ 31_ VQELV 36_ TVQEG 41_ LCVHV 46_ PCSFS 51_ YPQDG 56_ WTDSD 61_ PVHGY 66_ WFRAG 71_ DRPYQ 76_ DAPVA 81_ TNNPD 86_ REVQA 91_ ETQGR 96_ FQLLG 101_ DIWSN 106_ DCSLS 111_ IRDAR 116_ KRDKG 121_ SYFFR 126_ LERGS 131_ MKWSY 136_ KSQLN 141_ YKTKQ 146_ LSVFV 151_ TALTH 156_ RPDIL 161_ ILGTL 166_ ESGHS 171_ RNLTC 176_ SVPWA 181_ CKQGT 186_ PPMIS 191_ WIGAS 196_ VSSPG 201_ PTTAR 206_ SSVLT 211_ LTPKP 216_ QDHGT 221_ SLTCQ 226_ VTLPG 231_ TGVTT 236_ TSTVR 241_ LDVSY 246_ PPWNL 251_ TMTVF 256_ QGDAT 261_ ASTAL 266_ GNGSS 271_ LSVLE 276_ GQSLR 281_ LVCAV 286_ NSNPP 291_ ARLSW 296_ TRGSL 301_ TLCPS 306_ RSSNP 311_ GLLEL 316_ PRVHV 321_ RDEGE 326_ FTCRA 331_ QNAQG 336_ SQHIS 341_ LSLSL 346_ QNEGT 351_ GTSRP 356_ VSQVT 361_ LAAVG 366_ GAGAT 371_ ALAFL 376_ SFCII 381_ FIIVR 386_ SCRKK 391_ SARPA 396_ AGVGD 401_ TGMED 406_ AKAIR 411_ GSASQ 416_ GPLTE 421_ SWKDG 426_ NPLKK 431_ PPPAV 436_ APSSG 441_ EEGEL 446_ HYATL 451_ SFHKV 456_ KPQDP 461_ QGQEA 466_ TDSEY 471_ SEIKI 476_ HKRET 481_ AETQA 486_ CLRNH 491_NPSSK
1: Putative adhesion molecule that mediates sialic-acid dependent binding to blood cells (PubMed:10625619, PubMed:10856141). Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619). Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658)