Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)
1_MKHYE 6_ VEILD 11_ AKTRE 16_ KLCFL 21_ DKVEP 26_ HATIA 31_ EIKNL 36_ FTKTH 41_ PQWYP 46_ ARQSL 51_ RLDPK 56_ GKSLK 61_ DEDVL 66_ QKLPV 71_ GTTAT 76_ LYFRD 81_ LGAQI 86_ SWVTV 91_ FLTEY 96_ AGPLF 101_ IYLLF 106_ YFRVP 111_ FIYGH 116_ KYDFT 121_ SSRHT 126_ VVHLA 131_ CICHS 136_ FHYIK 141_ RLLET 146_ LFVHR 151_ FSHGT 156_ MPLRN 161_ IFKNC 166_ TYYWG 171_ FAAWM 176_ AYYIN 181_ HPLYT 186_ PPTYG 191_ AQQVK 196_ LALAI 201_ FVICQ 206_ LGNFS 211_ IHMAL 216_ RDLRP 221_ AGSKT 226_ RKIPY 231_ PTKNP 236_ FTWLF 241_ LLVSC 246_ PNYTY 251_ EVGSW 256_ IGFAI 261_ MTQCL 266_ PVALF 271_ SLVGF 276_ TQMTI 281_ WAKGK 286_ HRSYL 291_ KEFRD 296_ YPPLR 301_MPIIP
1: Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (PubMed:25049234). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (PubMed:12482854). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (PubMed:12482854). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (PubMed:12482854). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (PubMed:12482854). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (PubMed:25049234)