Endoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-) (ARTS-1) (Adipocyte-derived leucine aminopeptidase) (A-LAP) (Aminopeptidase PILS) (Puromycin-insensitive leucyl-specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator)
1_MVFLP 6_ LKWSL 11_ ATMSF 16_ LLSSL 21_ LALLT 26_ VSTPS 31_ WCQST 36_ EASPK 41_ RSDGT 46_ PFPWN 51_ KIRLP 56_ EYVIP 61_ VHYDL 66_ LIHAN 71_ LTTLT 76_ FWGTT 81_ KVEIT 86_ ASQPT 91_ STIIL 96_ HSHHL 101_ QISRA 106_ TLRKG 111_ AGERL 116_ SEEPL 121_ QVLEH 126_ PRQEQ 131_ IALLA 136_ PEPLL 141_ VGLPY 146_ TVVIH 151_ YAGNL 156_ SETFH 161_ GFYKS 166_ TYRTK 171_ EGELR 176_ ILAST 181_ QFEPT 186_ AARMA 191_ FPCFD 196_ EPAFK 201_ ASFSI 206_ KIRRE 211_ PRHLA 216_ ISNMP 221_ LVKSV 226_ TVAEG 231_ LIEDH 236_ FDVTV 241_ KMSTY 246_ LVAFI 251_ ISDFE 256_ SVSKI 261_ TKSGV 266_ KVSVY 271_ AVPDK 276_ INQAD 281_ YALDA 286_ AVTLL 291_ EFYED 296_ YFSIP 301_ YPLPK 306_ QDLAA 311_ IPDFQ 316_ SGAME 321_ NWGLT 326_ TYRES 331_ ALLFD 336_ AEKSS 341_ ASSKL 346_ GITMT 351_ VAHEL 356_ AHQWF 361_ GNLVT 366_ MEWWN 371_ DLWLN 376_ EGFAK 381_ FMEFV 386_ SVSVT 391_ HPELK 396_ VGDYF 401_ FGKCF 406_ DAMEV 411_ DALNS 416_ SHPVS 421_ TPVEN 426_ PAQIR 431_ EMFDD 436_ VSYDK 441_ GACIL 446_ NMLRE 451_ YLSAD 456_ AFKSG 461_ IVQYL 466_ QKHSY 471_ KNTKN 476_ EDLWD 481_ SMASI 486_ CPTDG 491_ VKGMD 496_ GFCSR 501_ SQHSS 506_ SSSHW 511_ HQEGV 516_ DVKTM 521_ MNTWT 526_ LQKGF 531_ PLITI 536_ TVRGR 541_ NVHMK 546_ QEHYM 551_ KGSDG 556_ APDTG 561_ YLWHV 566_ PLTFI 571_ TSKSD 576_ MVHRF 581_ LLKTK 586_ TDVLI 591_ LPEEV 596_ EWIKF 601_ NVGMN 606_ GYYIV 611_ HYEDD 616_ GWDSL 621_ TGLLK 626_ GTHTA 631_ VSSND 636_ RASLI 641_ NNAFQ 646_ LVSIG 651_ KLSIE 656_ KALDL 661_ SLYLK 666_ HETEI 671_ MPVFQ 676_ GLNEL 681_ IPMYK 686_ LMEKR 691_ DMNEV 696_ ETQFK 701_ AFLIR 706_ LLRDL 711_ IDKQT 716_ WTDEG 721_ SVSER 726_ MLRSQ 731_ LLLLA 736_ CVHNY 741_ QPCVQ 746_ RAEGY 751_ FRKWK 756_ ESNGN 761_ LSLPV 766_ DVTLA 771_ VFAVG 776_ AQSTE 781_ GWDFL 786_ YSKYQ 791_ FSLSS 796_ TEKSQ 801_ IEFAL 806_ CRTQN 811_ KEKLQ 816_ WLLDE 821_ SFKGD 826_ KIKTQ 831_ EFPQI 836_ LTLIG 841_ RNPVG 846_ YPLAW 851_ QFLRK 856_ NWNKL 861_ VQKFE 866_ LGSSS 871_ IAHMV 876_ MGTTN 881_ QFSTR 886_ TRLEE 891_ VKGFF 896_ SSLKE 901_ NGSQL 906_ RCVQQ 911_ TIETI 916_ EENIG 921_ WMDKN 926_ FDKIR 931_ VWLQS 936_EKLER
1: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney