Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2)
1_MNLER 6_ VSNEE 11_ KLNLC 16_ RKYYL 21_ GGFAF 26_ LPFLW 31_ LVNIF 36_ WFFRE 41_ AFLVP 46_ AYTEQ 51_ SQIKG 56_ YVWRS 61_ AVGFL 66_ FWVIV 71_ LTSWI 76_ TIFQI 81_ YRPRW 86_ GALGD 91_ YLSFT 96_IPLGT
1: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:12679784, PubMed:12740439, PubMed:12763021, PubMed:24941111, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12679784, PubMed:12740439, PubMed:12763021, PubMed:24941111)