ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)
1_MAEAE 6_ GESLE 11_ SWLNK 16_ ATNPS 21_ NRQED 26_ WEYII 31_ GFCDQ 36_ INKEL 41_ EGPQI 46_ AVRLL 51_ AHKIQ 56_ SPQEW 61_ EALQA 66_ LTVLE 71_ ACMKN 76_ CGRRF 81_ HNEVG 86_ KFRFL 91_ NELIK 96_ VVSPK 101_ YLGDR 106_ VSEKV 111_ KTKVI 116_ ELLYS 121_ WTMAL 126_ PEEAK 131_ IKDAY 136_ HMLKR 141_ QGIVQ 146_ SDPPI 151_ PVDRT 156_ LIPSP 161_ PPRPK 166_ NPVFD 171_ DEEKS 176_ KLLAK 181_ LLKSK 186_ NPDDL 191_ QEANK 196_ LIKSM 201_ VKEDE 206_ ARIQK 211_ VTKRL 216_ HTLEE 221_ VNNNV 226_ RLLSE 231_ MLLHY 236_ SQEDS 241_ SDGDR 246_ ELMKE 251_ LFDQC 256_ ENKRR 261_ TLFKL 266_ ASETE 271_ DNDNS 276_ LGDIL 281_ QASDN 286_ LSRVI 291_ NSYKT 296_ IIEGQ 301_ VINGE 306_ VATLT 311_ LPDSE 316_ GNSQC 321_ SNQGT 326_ LIDLA 331_ ELDTT 336_ NSLSS 341_ VLAPA 346_ PTPPS 351_ SGIPI 356_ LPPPP 361_ QASGP 366_ PRSRS 371_ SSQAE 376_ ATLGP 381_ SSTSN 386_ ALSWL 391_ DEELL 396_ CLGLA 401_ DPAPN 406_ VPPKE 411_ SAGNS 416_ QWHLL 421_ QREQS 426_ DLDFF 431_ SPRPG 436_ TAACG 441_ ASDAP 446_ LLQPS 451_ APSSS 456_ SSQAP 461_ LPPPF 466_ PAPVV 471_ PASVP 476_ APSAG 481_ SSLFS 486_ TGVAP 491_ ALAPK 496_ VEPAV 501_ PGHHG 506_ LALGN 511_ SALHH 516_ LDALD 521_ QLLEE 526_ AKVTS 531_ GLVKP 536_ TTSPL 541_ IPTTT 546_ PARPL 551_ LPFST 556_ GPGSP 561_ LFQPL 566_ SFQSQ 571_ GSPPK 576_ GPELS 581_ LASIH 586_ VPLES 591_ IKPSS 596_ ALPVT 601_ AYDKN 606_ GFRIL 611_ FHFAK 616_ ECPPG 621_ RPDVL 626_ VVVVS 631_ MLNTA 636_ PLPVK 641_ SIVLQ 646_ AAVPK 651_ SMKVK 656_ LQPPS 661_ GTELS 666_ PFSPI 671_ QPPAA 676_ ITQVM 681_ LLANP 686_ LKEKV 691_ RLRYK 696_ LTFAL 701_ GEQLS 706_ TEVGE 711_ VDQFP 716_PVEQW
1: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:15615712, PubMed:17553422, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity)