Regulator of telomere elongation helicase 1 (EC 3.6.4.12) (Novel helicase-like)
1_MPKIV 6_ LNGVT 11_ VDFPF 16_ QPYKC 21_ QQEYM 26_ TKVLE 31_ CLQQK 36_ VNGIL 41_ ESPTG 46_ TGKTL 51_ CLLCT 56_ TLAWR 61_ EHLRD 66_ GISAR 71_ KIAER 76_ AQGEL 81_ FPDRA 86_ LSSWG 91_ NAAAA 96_ AGDPI 101_ ACYTD 106_ IPKII 111_ YASRT 116_ HSQLT 121_ QVINE 126_ LRNTS 131_ YRPKV 136_ CVLGS 141_ REQLC 146_ IHPEV 151_ KKQES 156_ NHLQI 161_ HLCRK 166_ KVASR 171_ SCHFY 176_ NNVEE 181_ KSLEQ 186_ ELASP 191_ ILDIE 196_ DLVKS 201_ GSKHR 206_ VCPYY 211_ LSRNL 216_ KQQAD 221_ IIFMP 226_ YNYLL 231_ DAKSR 236_ RAHNI 241_ DLKGT 246_ VVIFD 251_ EAHNV 256_ EKMCE 261_ ESASF 266_ DLTPH 271_ DLASG 276_ LDVID 281_ QVLEE 286_ QTKAA 291_ QQGEP 296_ HPEFS 301_ ADSPS 306_ PGLNM 311_ ELEDI 316_ AKLKM 321_ ILLRL 326_ EGAID 331_ AVELP 336_ GDDSG 341_ VTKPG 346_ SYIFE 351_ LFAEA 356_ QITFQ 361_ TKGCI 366_ LDSLD 371_ QIIQH 376_ LAGRA 381_ GVFTN 386_ TAGLQ 391_ KLADI 396_ IQIVF 401_ SVDPS 406_ EGSPG 411_ SPAGL 416_ GALQS 421_ YKVHI 426_ HPDAG 431_ HRRTA 436_ QRSDA 441_ WSTTA 446_ ARKRG 451_ KVLSY 456_ WCFSP 461_ GHSMH 466_ ELVRQ 471_ GVRSL 476_ ILTSG 481_ TLAPV 486_ SSFAL 491_ EMQIP 496_ FPVCL 501_ ENPHI 506_ IDKHQ 511_ IWVGV 516_ VPRGP 521_ DGAQL 526_ SSAFD 531_ RRFSE 536_ ECLSS 541_ LGKAL 546_ GNIAR 551_ VVPYG 556_ LLIFF 561_ PSYPV 566_ MEKSL 571_ EFWRA 576_ RDLAR 581_ KMEAL 586_ KPLFV 591_ EPRSK 596_ GSFSE 601_ TISAY 606_ YARVA 611_ APGST 616_ GATFL 621_ AVCRG 626_ KASEG 631_ LDFSD 636_ TNGRG 641_ VIVTG 646_ LPYPP 651_ RMDPR 656_ VVLKM 661_ QFLDE 666_ MKGQG 671_ GAGGQ 676_ FLSGQ 681_ EWYRQ 686_ QASRA 691_ VNQAI 696_ GRVIR 701_ HRQDY 706_ GAVFL 711_ CDHRF 716_ AFADA 721_ RAQLP 726_ SWVRP 731_ HVRVY 736_ DNFGH 741_ VIRDV 746_ AQFFR 751_ VAERT 756_ MPAPA 761_ PRATA 766_ PSVRG 771_ EDAVS 776_ EAKSP 781_ GPFFS 786_ TRKAK 791_ SLDLH 796_ VPSLK 801_ QRSSG 806_ SPAAG 811_ DPESS 816_ LCVEY 821_ EQEPV 826_ PARQR 831_ PRGLL 836_ AALEH 841_ SEQRA 846_ GSPGE 851_ EQAHS 856_ CSTLS 861_ LLSEK 866_ RPAEE 871_ PRGGR 876_ KKIRL 881_ VSHPE 886_ EPVAG 891_ AQTDR 896_ AKLFM 901_ VAVKQ 906_ ELSQA 911_ NFATF 916_ TQALQ 921_ DYKGS 926_ DDFAA 931_ LAACL 936_ GPLFA 941_ EDPKK 946_ HNLLQ 951_ GFYQF 956_ VRPHH 961_ KQQFE 966_ EVCIQ 971_ LTGRG 976_ CGYRP 981_ EHSIP 986_ RRQRA 991_ QPVLD 996_ PTGRT 1001_ APDPK 1006_ LTVST 1011_ AAAQQ 1016_ LDPQE 1021_ HLNQG 1026_ RPHLS 1031_ PRPPP 1036_ TGDPG 1041_ SQPQW 1046_ GSGVP 1051_ RAGKQ 1056_ GQHAV 1061_ SAYLA 1066_ DARRA 1071_ LGSAG 1076_ CSQLL 1081_ AALTA 1086_ YKQDD 1091_ DLDKV 1096_ LAVLA 1101_ ALTTA 1106_ KPEDF 1111_ PLLHR 1116_ FSMFV 1121_ RPHHK 1126_ QRFSQ 1131_ TCTDL 1136_ TGRPY 1141_ PGMEP 1146_ PGPQE 1151_ ERLAV 1156_ PPVLT 1161_ HRAPQ 1166_ PGPSR 1171_ SEKTG 1176_ KTQSK 1181_ ISSFL 1186_ RQRPA 1191_ GTVGA 1196_ GGEDA 1201_ GPSQS 1206_ SGPPH 1211_GPAAS
1: A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere