Chloride intracellular channel protein 5
1_MNDED 6_ YSTIY 11_ DTIQN 16_ ERTYE 21_ VPDQP 26_ EENES 31_ PHYDD 36_ VHEYL 41_ RPEND 46_ LYATQ 51_ LNTHE 56_ YDFVS 61_ VYTIK 66_ GEETS 71_ LASVQ 76_ SEDRG 81_ YLLPD 86_ EIYSE 91_ LQEAH 96_ PGEPQ 101_ EDRGI 106_ SMEGL 111_ YSSTQ 116_ DQQLC 121_ AAELQ 126_ ENGSV 131_ MKEDL 136_ PSPSS 141_ FTIQH 146_ SKAFS 151_ TTKYS 156_ CYSDA 161_ EGLEE 166_ KEGAH 171_ MNPEI 176_ YLFVK 181_ AGIDG 186_ ESIGN 191_ CPFSQ 196_ RLFMI 201_ LWLKG 206_ VVFNV 211_ TTVDL 216_ KRKPA 221_ DLHNL 226_ APGTH 231_ PPFLT 236_ FNGDV 241_ KTDVN 246_ KIEEF 251_ LEETL 256_ TPEKY 261_ PKLAA 266_ KHRES 271_ NTAGI 276_ DIFSK 281_ FSAYI 286_ KNTKQ 291_ QNNAA 296_ LERGL 301_ TKALK 306_ KLDDY 311_ LNTPL 316_ PEEID 321_ ANTCG 326_ EDKGS 331_ RRKFL 336_ DGDEL 341_ TLADC 346_ NLLPK 351_ LHVVK 356_ IVAKK 361_ YRNYD 366_ IPAEM 371_ TGLWR 376_ YLKNA 381_ YARDE 386_ FTNTC 391_ AADSE 396_ IELAY 401_ADVAK
1: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form non-selective ion channels almost equally permeable to Na(+), K(+) and Cl(-) (PubMed:15184393, PubMed:18028448). Required for normal hearing (PubMed:24781754). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315). Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (By similarity)