Glycerophosphodiester phosphodiesterase 1 (Glycerophosphoinositol glycerophosphodiesterase GDE1) (EC 3.1.4.44) (Lysophospholipase D GDE1) (EC 3.1.4.-) (Membrane-interacting protein of RGS16) (RGS16-interacting membrane protein)
1_MWLWE 6_ DQGGL 11_ LGPFS 16_ FLLLV 21_ LLLVT 26_ RSPVN 31_ ACLLT 36_ GSLFV 41_ LLRVF 46_ SFEPV 51_ PSCRA 56_ LQVLK 61_ PRDRI 66_ SAIAH 71_ RGGSH 76_ DAPEN 81_ TLAAI 86_ RQAAK 91_ NGATG 96_ VELDI 101_ EFTSD 106_ GIPVL 111_ MHDNT 116_ VDRTT 121_ DGTGR 126_ LCDLT 131_ FEQIR 136_ KLNPA 141_ ANHRL 146_ RNDFP 151_ DEKIP 156_ TLREA 161_ VAECL 166_ NHNLT 171_ IFFDV 176_ KGHAH 181_ KATEA 186_ LKKMY 191_ MEFPQ 196_ LYNNS 201_ VVCSF 206_ LPEVI 211_ YKMRQ 216_ TDRDV 221_ ITALT 226_ HRPWS 231_ LSHTG 236_ DGKPR 241_ YDTFW 246_ KHFIF 251_ VMMDI 256_ LLDWS 261_ MHNIL 266_ WYLCG 271_ ISAFL 276_ MQKDF 281_ VSPAY 286_ LKKWS 291_ AKGIQ 296_ VVGWT 301_ VNTFD 306_ EKSYY 311_ ESHLG 316_ SSYIT 321_ DSMVE 326_DCEPH
1: Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity). Has little or no activity towards glycerophosphocholine (By similarity)