ETS homologous factor (hEHF) (ETS domain-containing transcription factor) (Epithelium-specific Ets transcription factor 3) (ESE-3)
1_MILEG 6_ GGVMN 11_ LNPGN 16_ NLLHQ 21_ PPAWT 26_ DSYST 31_ CNVSS 36_ GFFGG 41_ QWHEI 46_ HPQYW 51_ TKYQV 56_ WEWLQ 61_ HLLDT 66_ NQLDA 71_ NCIPF 76_ QEFDI 81_ NGEHL 86_ CSMSL 91_ QEFTR 96_ AAGTA 101_ GQLLY 106_ SNLQH 111_ LKWNG 116_ QCSSD 121_ LFQST 126_ HNVIV 131_ KTEQT 136_ EPSIM 141_ NTWKD 146_ ENYLY 151_ DTNYG 156_ STVDL 161_ LDSKT 166_ FCRAQ 171_ ISMTT 176_ TSHLP 181_ VAESP 186_ DMKKE 191_ QDPPA 196_ KCHTK 201_ KHNPR 206_ GTHLW 211_ EFIRD 216_ ILLNP 221_ DKNPG 226_ LIKWE 231_ DRSEG 236_ VFRFL 241_ KSEAV 246_ AQLWG 251_ KKKNN 256_ SSMTY 261_ EKLSR 266_ AMRYY 271_ YKREI 276_ LERVD 281_ GRRLV 286_ YKFGK 291_NARGW
1: Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene