WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase) (Short chain dehydrogenase/reductase family 41C member 1)
1_MAALR 6_ YAGLD 11_ DTDSE 16_ DELPP 21_ GWEER 26_ TTKDG 31_ WVYYA 36_ NHTEE 41_ KTQWE 46_ HPKTG 51_ KRKRV 56_ AGDLP 61_ YGWEQ 66_ ETDEN 71_ GQVFF 76_ VDHIN 81_ KRTTY 86_ LDPRL 91_ AFTVD 96_ DNPTK 101_ PTTRQ 106_ RYDGS 111_ TTAME 116_ ILQGR 121_ DFTGK 126_ VVVVT 131_ GANSG 136_ IGFET 141_ AKSFA 146_ LHGAH 151_ VILAC 156_ RNMAR 161_ ASEAV 166_ SRILE 171_ EWHKA 176_ KVEAM 181_ TLDLA 186_ LLRSV 191_ QHFAE 196_ AFKAK 201_ NVPLH 206_ VLVCN 211_ AATFA 216_ LPWSL 221_ TKDGL 226_ ETTFQ 231_ VNHLG 236_ HFYLV 241_ QLLQD 246_ VLCRS 251_ APARV 256_ IVVSS 261_ ESHRF 266_ TDIND 271_ SLGKL 276_ DFSRL 281_ SPTKN 286_ DYWAM 291_ LAYNR 296_ SKLCN 301_ ILFSN 306_ ELHRR 311_ LSPRG 316_ VTSNA 321_ VHPGN 326_ MMYSN 331_ IHRSW 336_ WVYTL 341_ LFTLA 346_ RPFTK 351_ SMQQG 356_ AATTV 361_ YCAAV 366_ PELEG 371_ LGGMY 376_ FNNCC 381_ RCMPS 386_ PEAQS 391_ EETAR 396_ TLWAL 401_ SERLI 406_QERLG
1: Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm