Ninjurin-2 (Nerve injury-induced protein 2)
1_MESAR 6_ ENIDL 11_ QPGSS 16_ DPRSQ 21_ PINLN 26_ HYATK 31_ KSVAE 36_ SMLDV 41_ ALFMS 46_ NAMRL 51_ KAVLE 56_ QGPSS 61_ HYYTT 66_ LVTLI 71_ SLSLL 76_ LQVVI 81_ GVLLV 86_ VIARL 91_ NLNEV 96_ EKQWR 101_ LNQLN 106_ NAATI 111_ LVFFT 116_ VVINV 121_ FITAF 126_ GAHKT 131_ GFLAA 136_RASRN
1: Its role in unclear (PubMed:33472215, PubMed:38614101, PubMed:39667936). In contrast to NINJ1 paralog, does not mediate plasma membrane rupture (cytolysis) downstream of necroptotic and pyroptotic programmed cell death (PubMed:33472215, PubMed:38614101, PubMed:39667936). While it is able to oligomerize and form filaments, filaments are curved toward the intracellular space, preventing circularization to mediate plasma membrane rupture (PubMed:39667936). May act as a homophilic transmembrane adhesion molecule involved in nerve regeneration (PubMed:10627596). Promotes axonal growth (PubMed:10627596)