Interleukin-37 (IL-37) (FIL1 zeta) (IL-1X) (Interleukin-1 family member 7) (IL-1F7) (Interleukin-1 homolog 4) (IL-1H) (IL-1H4) (Interleukin-1 zeta) (IL-1 zeta) (Interleukin-1-related protein) (IL-1RP1) (Interleukin-23) (IL-23)
1_MSFVG 6_ ENSGV 11_ KMGSE 16_ DWEKD 21_ EPQCC 26_ LEDPA 31_ GSPLE 36_ PGPSL 41_ PTMNF 46_ VHTSP 51_ KVKNL 56_ NPKKF 61_ SIHDQ 66_ DHKVL 71_ VLDSG 76_ NLIAV 81_ PDKNY 86_ IRPEI 91_ FFALA 96_ SSLSS 101_ ASAEK 106_ GSPIL 111_ LGVSK 116_ GEFCL 121_ YCDKD 126_ KGQSH 131_ PSLQL 136_ KKEKL 141_ MKLAA 146_ QKESA 151_ RRPFI 156_ FYRAQ 161_ VGSWN 166_ MLESA 171_ AHPGW 176_ FICTS 181_ CNCNE 186_ PVGVT 191_ DKFEN 196_ RKHIE 201_ FSFQP 206_ VCKAE 211_MSPSE
1: Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. Signaling can occur via two mechanisms, intracellularly through nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor composed of IL18R1 and IL18RAP. Suppresses, or reduces, pro-inflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation