Interleukin-36 beta (FIL1 eta) (Interleukin-1 eta) (IL-1 eta) (Interleukin-1 family member 8) (IL-1F8) (Interleukin-1 homolog 2) (IL-1H2)
1_MNPQR 6_ EAAPK 11_ SYAIR 16_ DSRQM 21_ VWVLS 26_ GNSLI 31_ AAPLS 36_ RSIKP 41_ VTLHL 46_ IACRD 51_ TEFSD 56_ KEKGN 61_ MVYLG 66_ IKGKD 71_ LCLFC 76_ AEIQG 81_ KPTLQ 86_ LKLQG 91_ SQDNI 96_ GKDTC 101_ WKLVG 106_ IHTCI 111_ NLDVR 116_ ESCFM 121_ GTLDQ 126_ WGIGV 131_ GRKKW 136_ KSSFQ 141_ HHHLR 146_ KKDKD 151_ FSSMR 156_TNIGM
1: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6