Interleukin-36 gamma (IL-1-related protein 2) (IL-1RP2) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 9) (IL-1F9) (Interleukin-1 homolog 1) (IL-1H1)
1_MRGTP 6_ GDADG 11_ GGRAV 16_ YQSMC 21_ KPITG 26_ TINDL 31_ NQQVW 36_ TLQGQ 41_ NLVAV 46_ PRSDS 51_ VTPVT 56_ VAVIT 61_ CKYPE 66_ ALEQG 71_ RGDPI 76_ YLGIQ 81_ NPEMC 86_ LYCEK 91_ VGEQP 96_ TLQLK 101_ EQKIM 106_ DLYGQ 111_ PEPVK 116_ PFLFY 121_ RAKTG 126_ RTSTL 131_ ESVAF 136_ PDWFI 141_ ASSKR 146_ DQPII 151_ LTSEL 156_ GKSYN 161_TAFEL
1: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous pro-inflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in pro-inflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus