Grainyhead-like protein 1 homolog (Mammalian grainyhead) (NH32) (Transcription factor CP2-like 2) (Transcription factor LBP-32)
1_MTQEY 6_ DNKRP 11_ VLVLQ 16_ NEALY 21_ PQRRS 26_ YTSED 31_ EAWKS 36_ FLENP 41_ LTAAT 46_ KAMMS 51_ INGDE 56_ DSAAA 61_ LGLLY 66_ DYYKV 71_ PRERR 76_ SSTAK 81_ PEVEH 86_ PEPDH 91_ SKRNS 96_ IPIVT 101_ EQPLI 106_ SAGEN 111_ RVQVL 116_ KNVPF 121_ NIVLP 126_ HGNQL 131_ GIDKR 136_ GHLTA 141_ PDTTV 146_ TVSIA 151_ TMPTH 156_ SIKTE 161_ TQPHG 166_ FAVGI 171_ PPAVY 176_ HPEPT 181_ ERVVV 186_ FDRNL 191_ NTDQF 196_ SSGAQ 201_ APNAQ 206_ RRTPD 211_ STFSE 216_ TFKEG 221_ VQEVF 226_ FPSDL 231_ SLRMP 236_ GMNSE 241_ DYVFD 246_ SVSGN 251_ NFEYT 256_ LEASK 261_ SLRQK 266_ PGDST 271_ MTYLN 276_ KGQFY 281_ PITLK 286_ EVSSS 291_ EGIHH 296_ PISKV 301_ RSVIM 306_ VVFAE 311_ DKSRE 316_ DQLRH 321_ WKYWH 326_ SRQHT 331_ AKQRC 336_ IDIAD 341_ YKESF 346_ NTISN 351_ IEEIA 356_ YNAIS 361_ FTWDI 366_ NDEAK 371_ VFISV 376_ NCLST 381_ DFSSQ 386_ KGVKG 391_ LPLNI 396_ QVDTY 401_ SYNNR 406_ SNKPV 411_ HRAYC 416_ QIKVF 421_ CDKGA 426_ ERKIR 431_ DEERK 436_ QSKRK 441_ VSDVK 446_ VPLLP 451_ SHKRM 456_ DITVF 461_ KPFID 466_ LDTQP 471_ VLFIP 476_ DVHFA 481_ NLQRG 486_ THVLP 491_ IASEE 496_ LEGEG 501_ SVLKR 506_ GPYGT 511_ EDDFA 516_ VPPST 521_ KLARI 526_ EEPKR 531_ VLLYV 536_ RKESE 541_ EVFDA 546_ LMLKT 551_ PSLKG 556_ LMEAI 561_ SDKYD 566_ VPHDK 571_ IGKIF 576_ KKCKK 581_ GILVN 586_ MDDNI 591_ VKHYS 596_ NEDTF 601_ QLQIE 606_ EAGGS 611_YKLTL
1: Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204, PubMed:29309642). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, nor functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). May play a role in regulating glucose homeostasis and insulin signaling
2: Functions as a transcription activator
3: May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed