Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1) (Transcription factor LBP-9)
1_MLFWH 6_ TQPEH 11_ YNQHN 16_ SGSYL 21_ RDVLA 26_ LPIFK 31_ QEEPQ 36_ LSPEN 41_ EARLP 46_ PLQYV 51_ LCAAT 56_ SPAVK 61_ LHEET 66_ LTYLN 71_ QGQSY 76_ EIRLL 81_ ENRKL 86_ GDFQD 91_ LNTKY 96_ VKSII 101_ RVVFH 106_ DRRLQ 111_ YTEHQ 116_ QLEGW 121_ RWSRP 126_ GDRIL 131_ DIDIP 136_ LSVGI 141_ LDPRA 146_ SPTQL 151_ NAVEF 156_ LWDPA 161_ KRASA 166_ FIQVH 171_ CISTE 176_ FTPRK 181_ HGGEK 186_ GVPFR 191_ VQIDT 196_ FKQNE 201_ NGEYT 206_ EHLHS 211_ ASCQI 216_ KVFKP 221_ KGADR 226_ KQKTD 231_ REKME 236_ KRTAQ 241_ EKEKY 246_ QPSYE 251_ TTILT 256_ ECSPW 261_ PDVAY 266_ QVNSA 271_ PSPSY 276_ NGSPN 281_ SFGLG 286_ EGNAS 291_ PTHPV 296_ EALPV 301_ GSDHL 306_ LPSAS 311_ IQDAQ 316_ QWLHR 321_ NRFSQ 326_ FCRLF 331_ ASFSG 336_ ADLLK 341_ MSRDD 346_ LVQIC 351_ GPADG 356_ IRLFN 361_ AIKGR 366_ NVRPK 371_ MTIYV 376_ CQELE 381_ QNRVP 386_ LQQKR 391_ DGSGD 396_ SNLSV 401_ YHAIF 406_ LEELT 411_ TLELI 416_ EKIAN 421_ LYSIS 426_ PQHIH 431_ RVYRQ 436_ GPTGI 441_ HVVVS 446_ NEMVQ 451_ NFQDE 456_ SCFVL 461_ STIKA 466_ ESNDG 471_YHIIL
1: Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Also regulates the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1 (PubMed:10644752)