Ubiquinone biosynthesis O-methyltransferase, mitochondrial (3-demethylubiquinol 3-O-methyltransferase) (EC 2.1.1.64) (Polyprenyldihydroxybenzoate methyltransferase) (EC 2.1.1.114)
1_MWSGR 6_ KLGSS 11_ GGWFL 16_ RVLGP 21_ GGCNT 26_ KAARP 31_ LISSA 36_ VYVKN 41_ QLSGT 46_ LQIKP 51_ GVFNE 56_ YRTIW 61_ FKSYR 66_ TIFSC 71_ LNRIK 76_ SFRYP 81_ WARLY 86_ STSQT 91_ TVDSG 96_ EVKTF 101_ LALAH 106_ KWWDE 111_ QGVYA 116_ PLHSM 121_ NDLRV 126_ PFIRD 131_ NLLKT 136_ IPNHQ 141_ PGKPL 146_ LGMKI 151_ LDVGC 156_ GGGLL 161_ TEPLG 166_ RLGAS 171_ VIGID 176_ PVDEN 181_ IKTAQ 186_ CHKSF 191_ DPVLD 196_ KRIEY 201_ RVCSL 206_ EEIVE 211_ ETAET 216_ FDAVV 221_ ASEVV 226_ EHVID 231_ LETFL 236_ QCCCQ 241_ VLKPG 246_ GSLFI 251_ TTINK 256_ TQLSY 261_ ALGIV 266_ FSEQI 271_ ASIVP 276_ KGTHT 281_ WEKFV 286_ SPETL 291_ ESILE 296_ SNGLS 301_ VQTVV 306_ GMLYN 311_ PFSGY 316_ WHWSE 321_ NTSLN 326_ YAAYA 331_ VKSRV 336_ QEHPA 341_ SAEFV 346_ LKGET 351_ EELQA 356_ NACTN 361_PAVHE
1: O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis (By similarity) (PubMed:10777520, PubMed:38425362). Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid (By similarity) (PubMed:10777520, PubMed:38425362). Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone (By similarity) (PubMed:38425362). Also able to mediate the methylation of 3-demethylubiquinol-10 into ubiquinol-10 (By similarity) (PubMed:10777520)