Hsp70-binding protein 1 (HspBP1) (Heat shock protein-binding protein 1) (Hsp70-binding protein 2) (HspBP2) (Hsp70-interacting protein 1) (Hsp70-interacting protein 2)
1_MSDEG 6_ SRGSR 11_ LPLAL 16_ PPASQ 21_ GCSSG 26_ GGGGG 31_ SSAGG 36_ SGNSR 41_ PPRNL 46_ QGLLQ 51_ MAITA 56_ GSEEP 61_ DPPPE 66_ PMSEE 71_ RRQWL 76_ QEAMS 81_ AAFRG 86_ QREEV 91_ EQMKS 96_ CLRVL 101_ SQPMP 106_ PTAGE 111_ AEQAA 116_ DQQER 121_ EGALE 126_ LLADL 131_ CENMD 136_ NAADF 141_ CQLSG 146_ MHLLV 151_ GRYLE 156_ AGAAG 161_ LRWRA 166_ AQLIG 171_ TCSQN 176_ VAAIQ 181_ EQVLG 186_ LGALR 191_ KLLRL 196_ LDRDA 201_ CDTVR 206_ VKALF 211_ AISCL 216_ VREQE 221_ AGLLQ 226_ FLRLD 231_ GFSVL 236_ MRAMQ 241_ QQVQK 246_ LKVKS 251_ AFLLQ 256_ NLLVG 261_ HPEHK 266_ GTLCS 271_ MGMVQ 276_ QLVAL 281_ VRTEH 286_ SPFHE 291_ HVLGA 296_ LCSLV 301_ TDFPQ 306_ GVREC 311_ REPEL 316_ GLEEL 321_ LRHRC 326_ QLLQQ 331_ HEEYQ 336_ EELEF 341_ CEKLL 346_ QTCFS 351_SPADD
1: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR