Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60)
1_MAAGG 6_ SGVGG 11_ KRSSK 16_ SDADS 21_ GFLGL 26_ RPTSV 31_ DPALR 36_ RRRRG 41_ PRNKK 46_ RGWRR 51_ LAQEP 56_ LGLEV 61_ DQFLE 66_ DVRLQ 71_ ERTSG 76_ GLLSE 81_ APNEK 86_ LFFVD 91_ TGSKE 96_ KGLTK 101_ KRTKV 106_ QKKSL 111_ LLKKP 116_ LRVDL 121_ ILENT 126_ SKVPA 131_ PKDVL 136_ AHQVP 141_ NAKKL 146_ RRKEQ 151_ LWEKL 156_ AKQGE 161_ LPREV 166_ RRAQA 171_ RLLNP 176_ SATRA 181_ KPGPQ 186_ DTVER 191_ PFYDL 196_ WASDN 201_ PLDRP 206_ LVGQD 211_ EFFLE 216_ QTKKK 221_ GVKRP 226_ ARLHT 231_ KPSQA 236_ PAVEV 241_ APAGA 246_ SYNPS 251_ FEDHQ 256_ TLLSA 261_ AHEVE 266_ LQRQK 271_ EAEKL 276_ ERQLA 281_ LPATE 286_ QAATQ 291_ ESTFQ 296_ ELCEG 301_ LLEES 306_ DGEGE 311_ PGQGE 316_ GPEAG 321_ DAEVC 326_ PTPAR 331_ LATTE 336_ KKTEQ 341_ QRRRE 346_ KAVHR 351_ LRVQQ 356_ AALRA 361_ ARLRH 366_ QELFR 371_ LRGIK 376_ AQVAL 381_ RLAEL 386_ ARRQR 391_ RRQAR 396_ REAEA 401_ DKPRR 406_ LGRLK 411_ YQAPD 416_ IDVQL 421_ SSELT 426_ DSLRT 431_ LKPEG 436_ NILRD 441_ RFKSF 446_ QRRNM 451_ IEPRE 456_ RAKFK 461_ RKYKV 466_ KLVEK 471_RAFRE
1: Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611). May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305). May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168). Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029). May also regulate cellular aerobic respiration (PubMed:24556985). In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI (PubMed:27824081)