EH domain-containing protein 3 (PAST homolog 3)
1_MFSWL 6_ GTDDR 11_ RRKDP 16_ EVFQT 21_ VSEGL 26_ KKLYK 31_ SKLLP 36_ LEEHY 41_ RFHEF 46_ HSPAL 51_ EDADF 56_ DNKPM 61_ VLLVG 66_ QYSTG 71_ KTTFI 76_ RYLLE 81_ QDFPG 86_ MRIGP 91_ EPTTD 96_ SFIAV 101_ MQGDM 106_ EGIIP 111_ GNALV 116_ VDPKK 121_ PFRKL 126_ NAFGN 131_ AFLNR 136_ FVCAQ 141_ LPNPV 146_ LESIS 151_ VIDTP 156_ GILSG 161_ EKQRI 166_ SRGYD 171_ FAAVL 176_ EWFAE 181_ RVDRI 186_ ILLFD 191_ AHKLD 196_ ISDEF 201_ SEVIK 206_ ALKNH 211_ EDKMR 216_ VVLNK 221_ ADQIE 226_ TQQLM 231_ RVYGA 236_ LMWSL 241_ GKIVN 246_ TPEVI 251_ RVYIG 256_ SFWSH 261_ PLLIP 266_ DNRKL 271_ FEAEE 276_ QDLFR 281_ DIQSL 286_ PRNAA 291_ LRKLN 296_ DLIKR 301_ ARLAK 306_ VHAYI 311_ ISSLK 316_ KEMPS 321_ VFGKD 326_ NKKKE 331_ LVNNL 336_ AEIYG 341_ RIERE 346_ HQISP 351_ GDFPN 356_ LKRMQ 361_ DQLQA 366_ QDFSK 371_ FQPLK 376_ SKLLE 381_ VVDDM 386_ LAHDI 391_ AQLMV 396_ LVRQE 401_ ESQRP 406_ IQMVK 411_ GGAFE 416_ GTLHG 421_ PFGHG 426_ YGEGA 431_ GEGID 436_ DAEWV 441_ VARDK 446_ PMYDE 451_ IFYTL 456_ SPVDG 461_ KITGA 466_ NAKKE 471_ MVRSK 476_ LPNSV 481_ LGKIW 486_ KLADI 491_ DKDGM 496_ LDDDE 501_ FALAN 506_ HLIKV 511_ KLEGH 516_ ELPNE 521_ LPAHL 526_LPPSK
1: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250)