Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
1_MSGTQ 6_ STITD 11_ RFPLK 16_ KPIRH 21_ GSILN 26_ RESPT 31_ DKKQK 36_ VERIA 41_ SHDFD 46_ PTDSS 51_ SKKTK 56_ SSSEE 61_ SRSEI 66_ YGLVQ 71_ RCVII 76_ QKDDN 81_ GFGLT 86_ VSGDN 91_ PVFVQ 96_ SVKED 101_ GAAMR 106_ AGVQT 111_ GDRII 116_ KVNGT 121_ LVTHS 126_ NHLEV 131_ VKLIK 136_ SGSYV 141_ ALTVQ 146_ GRPPG 151_ SPQIP 156_ LADSE 161_ VEPSV 166_ IGHMS 171_ PIMTS 176_ PHSPG 181_ ASGNM 186_ ERITS 191_ PVLMG 196_ EENNV 201_ VHNQK 206_ VEILR 211_ KMLQK 216_ EQERL 221_ QLLQE 226_ DYNRT 231_ PAQRL 236_ LKEIQ 241_ EAKKH 246_ IPQLQ 251_ EQLSK 256_ ATGSA 261_ QDGAV 266_ VTPSR 271_ PLGDT 276_ LTVSE 281_ AETDP 286_ GDVLG 291_ RTDCS 296_ SGDAS 301_ RPSSD 306_ NADSP 311_ KSGPK 316_ ERIYL 321_ EENPE 326_ KSETI 331_ QDTDT 336_ QSLVG 341_ SPSTR 346_ IAPHI 351_ IGAED 356_ DDFGT 361_ EHEQI 366_ NGQCS 371_ CFQSI 376_ ELLKS 381_ RPAHL 386_ AVFLH 391_ HVVSQ 396_ FDPAT 401_ LLCYL 406_ YSDLY 411_ KHTNS 416_ KETRR 421_ IFLEF 426_ HQFFL 431_ DRSAH 436_ LKVSV 441_ PDEMS 446_ ADLEK 451_ RRPEL 456_ IPEDL 461_ HRHYI 466_ QTMQE 471_ RVHPE 476_ VQRHL 481_ EDFRQ 486_ KRSMG 491_ LTLAE 496_ SELTK 501_ LDAER 506_ DKDRL 511_ TLEKE 516_ RTCAE 521_ QIVAK 526_ IEEVL 531_ MTAQA 536_ VEEDK 541_ SSTMQ 546_ YVILM 551_ YMKHL 556_ GVKVK 561_ EPRNL 566_ EHKRG 571_ RIGFL 576_ PKIKQ 581_ SMKKD 586_ KEGEE 591_ KGKRR 596_ GFPSI 601_ LGPPR 606_ RPSRH 611_ DNSAI 616_ GRAME 621_ LQKAR 626_ HPKHL 631_ STPSS 636_ VSPEP 641_ QDSAK 646_ LRQSG 651_ LANEG 656_ TDAGY 661_ LPANS 666_ MSSVA 671_ SGASF 676_ SQEGG 681_ KENDT 686_ GSKQV 691_ GETSA 696_ PGDTL 701_ DGTPR 706_ TLNTV 711_ FDFPP 716_ PPLDQ 721_ VQEEE 726_ CEVER 731_ VTEHG 736_ TPKPF 741_ RKFDS 746_ VAFGE 751_ SQSED 756_ EQFEN 761_ DLETD 766_ PPNWQ 771_ QLVSR 776_ EVLLG 781_ LKPCE 786_ IKRQE 791_ VINEL 796_ FYTER 801_ AHVRT 806_ LKVLD 811_ QVFYQ 816_ RVSRE 821_ GILSP 826_ SELRK 831_ IFSNL 836_ EDILQ 841_ LHIGL 846_ NEQMK 851_ AVRKR 856_ NETSV 861_ IDQIG 866_ EDLLT 871_ WFSGP 876_ GEEKL 881_ KHAAA 886_ TFCSN 891_ QPFAL 896_ EMIKS 901_ RQKKD 906_ SRFQT 911_ FVQDA 916_ ESNPL 921_ CRRLQ 926_ LKDII 931_ PTQMQ 936_ RLTKY 941_ PLLLD 946_ NIAKY 951_ TEWPT 956_ EREKV 961_ KKAAD 966_ HCRQI 971_ LNYVN 976_ QAVKE 981_ AENKQ 986_ RLEDY 991_ QRRLD 996_ TSSLK 1001_ LSEYP 1006_ NVEEL 1011_ RNLDL 1016_ TKRKM 1021_ IHEGP 1026_ LVWKV 1031_ NRDKT 1036_ IDLYT 1041_ LLLED 1046_ ILVLL 1051_ QKQDD 1056_ RLVLR 1061_ CHSKI 1066_ LASTA 1071_ DSKHT 1076_ FSPVI 1081_ KLSTV 1086_ LVRQV 1091_ ATDNK 1096_ ALFVI 1101_ SMSDN 1106_ GAQIY 1111_ ELVAQ 1116_ TVSEK 1121_ TVWQD 1126_ LICRM 1131_ AASVK 1136_ EQSTK 1141_ PIPLP 1146_ QSTPG 1151_ EGDND 1156_ EEDPS 1161_ KLKEE 1166_ QHGIS 1171_ VTGLQ 1176_ SPDRD 1181_ LGLES 1186_ TLISS 1191_ KPQSH 1196_ SLSTS 1201_ GKSEV 1206_ RDLFV 1211_ AERQF 1216_ AKEQH 1221_ TDGTL 1226_ KEVGE 1231_ DYQIA 1236_ IPDSH 1241_ LPVSE 1246_ ERWAL 1251_ DALRN 1256_ LGLLK 1261_ QLLVQ 1266_ QLGLT 1271_ EKSVQ 1276_ EDWQH 1281_ FPRYR 1286_ TASQG 1291_ PQTDS 1296_ VIQNS 1301_ ENIKA 1306_ YHSGE 1311_ GHMPF 1316_ RTGTG 1321_ DIATC 1326_ YSPRT 1331_ STESF 1336_ APRDS 1341_ VGLAP 1346_ QDSQA 1351_ SNILV 1356_ MDHMI 1361_ MTPEM 1366_ PTMEP 1371_ EGGLD 1376_ DSGEH 1381_ FFDAR 1386_ EAHSD 1391_ ENPSE 1396_ GDGAV 1401_ NKEEK 1406_ DVNLR 1411_ ISGNY 1416_ LILDG 1421_ YDPVQ 1426_ ESSTD 1431_ EEVAS 1436_ SLTLQ 1441_ PMTGI 1446_ PAVES 1451_ THQQQ 1456_ HSPQN 1461_ THSDG 1466_ AISPF 1471_ TPEFL 1476_ VQQRW 1481_ GAMEY 1486_ SCFEI 1491_ QSPSS 1496_ CADSQ 1501_ SQIME 1506_ YIHKI 1511_ EADLE 1516_ HLKKV 1521_ EESYT 1526_ ILCQR 1531_ LAGSA 1536_LTDKH
1: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13