CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2)
1_MVRTD 6_ GHTLS 11_ EKRNY 16_ QVTNS 21_ MFGAS 26_ RKKFV 31_ EGVDS 36_ DYHDE 41_ NMYYS 46_ QSSMF 51_ PHRSE 56_ KDMLA 61_ SPSTS 66_ GQLSQ 71_ FGASL 76_ YGQQS 81_ ALGLP 86_ MRGMS 91_ NNTPQ 96_ LNRSL 101_ SQGTQ 106_ LPSHV 111_ TPTTG 116_ VPTMS 121_ LHTPP 126_ SPSRG 131_ ILPMN 136_ PRNMM 141_ NHSQV 146_ GQGIG 151_ IPSRT 156_ NSMSS 161_ SGLGS 166_ PNRSS 171_ PSIIC 176_ MPKQQ 181_ PSRQP 186_ FTVNS 191_ MSGFG 196_ MNRNQ 201_ AFGMN 206_ NSLSS 211_ NIFNG 216_ TDGSE 221_ NVTGL 226_ DLSDF 231_ PALAD 236_ RNRRE 241_ GSGNP 246_ TPLIN 251_ PLAGR 256_ APYVG 261_ MVTKP 266_ ANEQS 271_ QDFSI 276_ HNEDF 281_ PALPG 286_ SSYKD 291_ PTSSN 296_ DDSKS 301_ NLNTS 306_ GKTTS 311_ STDGP 316_ KFPGD 321_ KSSTT 326_ QNNNQ 331_ QKKGI 336_ QVLPD 341_ GRVTN 346_ IPQGM 351_ VTDQF 356_ GMIGL 361_ LTFIR 366_ AAETD 371_ PGMVH 376_ LALGS 381_ DLTTL 386_ GLNLN 391_ SPENL 396_ YPKFA 401_ SPWAS 406_ SPCRP 411_ QDIDF 416_ HVPSE 421_ YLTNI 426_ HIRDK 431_ LAAIK 436_ LGRYG 441_ EDLLF 446_ YLYYM 451_ NGGDV 456_ LQLLA 461_ AVELF 466_ NRDWR 471_ YHKEE 476_ RVWIT 481_ RAPGM 486_ EPTMK 491_ TNTYE 496_ RGTYY 501_ FFDCL 506_ NWRKV 511_ AKEFH 516_ LEYDK 521_ LEERP 526_ HLPST 531_FNYNP
1: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity