Transient receptor potential cation channel subfamily M member 5 (Long transient receptor potential channel 5) (LTrpC-5) (LTrpC5) (MLSN1- and TRP-related gene 1 protein)
1_MQDVQ 6_ GPRPG 11_ SPGDA 16_ EDRRE 21_ LGLHR 26_ GEVNF 31_ GGSGK 36_ KRGKF 41_ VRVPS 46_ GVAPS 51_ VLFDL 56_ LLAEW 61_ HLPAP 66_ NLVVS 71_ LVGEE 76_ QPFAM 81_ KSWLR 86_ DVLRK 91_ GLVKA 96_ AQSTG 101_ AWILT 106_ SALRV 111_ GLARH 116_ VGQAV 121_ RDHSL 126_ ASTST 131_ KVRVV 136_ AVGMA 141_ SLGRV 146_ LHRRI 151_ LEEAQ 156_ EDFPV 161_ HYPED 166_ DGGSQ 171_ GPLCS 176_ LDSNL 181_ SHFIL 186_ VEPGP 191_ PGKGD 196_ GLTEL 201_ RLRLE 206_ KHISE 211_ QRAGY 216_ GGTGS 221_ IEIPV 226_ LCLLV 231_ NGDPN 236_ TLERI 241_ SRAVE 246_ QAAPW 251_ LILVG 256_ SGGIA 261_ DVLAA 266_ LVNQP 271_ HLLVP 276_ KVAEK 281_ QFKEK 286_ FPSKH 291_ FSWED 296_ IVRWT 301_ KLLQN 306_ ITSHQ 311_ HLLTV 316_ YDFEQ 321_ EGSEE 326_ LDTVI 331_ LKALV 336_ KACKS 341_ HSQEP 346_ QDYLD 351_ ELKLA 356_ VAWDR 361_ VDIAK 366_ SEIFN 371_ GDVEW 376_ KSCDL 381_ EEVMV 386_ DALVS 391_ NKPEF 396_ VRLFV 401_ DNGAD 406_ VADFL 411_ TYGRL 416_ QELYR 421_ SVSRK 426_ SLLFD 431_ LLQRK 436_ QEEAR 441_ LTLAG 446_ LGTQQ 451_ AREPP 456_ AGPPA 461_ FSLHE 466_ VSRVL 471_ KDFLQ 476_ DACRG 481_ FYQDG 486_ RPGDR 491_ RRAEK 496_ GPAKR 501_ PTGQK 506_ WLLDL 511_ NQKSE 516_ NPWRD 521_ LFLWA 526_ VLQNR 531_ HEMAT 536_ YFWAM 541_ GQEGV 546_ AAALA 551_ ACKIL 556_ KEMSH 561_ LETEA 566_ EAARA 571_ TREAK 576_ YERLA 581_ LDLFS 586_ ECYSN 591_ SEARA 596_ FALLV 601_ RRNRC 606_ WSKTT 611_ CLHLA 616_ TEADA 621_ KAFFA 626_ HDGVQ 631_ AFLTR 636_ IWWGD 641_ MAAGT 646_ PILRL 651_ LGAFL 656_ CPALV 661_ YTNLI 666_ TFSEE 671_ APLRT 676_ GLEDL 681_ QDLDS 686_ LDTEK 691_ SPLYG 696_ LQSRV 701_ EELVE 706_ APRAQ 711_ GDRGP 716_ RAVFL 721_ LTRWR 726_ KFWGA 731_ PVTVF 736_ LGNVV 741_ MYFAF 746_ LFLFT 751_ YVLLV 756_ DFRPP 761_ PQGPS 766_ GPEVT 771_ LYFWV 776_ FTLVL 781_ EEIRQ 786_ GFFTD 791_ EDTHL 796_ VKKFT 801_ LYVGD 806_ NWNKC 811_ DMVAI 816_ FLFIV 821_ GVTCR 826_ MLPSA 831_ FEAGR 836_ TVLAM 841_ DFMVF 846_ TLRLI 851_ HIFAI 856_ HKQLG 861_ PKIIV 866_ VERMM 871_ KDVFF 876_ FLFFL 881_ SVWLV 886_ AYGVT 891_ TQALL 896_ HPHDG 901_ RLEWI 906_ FRRVL 911_ YRPYL 916_ QIFGQ 921_ IPLDE 926_ IDEAR 931_ VNCST 936_ HPLLL 941_ EDSPS 946_ CPSLY 951_ ANWLV 956_ ILLLV 961_ TFLLV 966_ TNVLL 971_ MNLLI 976_ AMFSY 981_ TFQVV 986_ QGNAD 991_ MFWKF 996_ QRYNL 1001_ IVEYH 1006_ ERPAL 1011_ APPFI 1016_ LLSHL 1021_ SLTLR 1026_ RVFKK 1031_ EAEHK 1036_ REHLE 1041_ RDLPD 1046_ PLDQK 1051_ VVTWE 1056_ TVQKE 1061_ NFLSK 1066_ MEKRR 1071_ RDSEG 1076_ EVLRK 1081_ TAHRV 1086_ DFIAK 1091_ YLGGL 1096_ REQEK 1101_ RIKCL 1106_ ESQIN 1111_ YCSVL 1116_ VSSVA 1121_ DVLAQ 1126_ GGGPR 1131_ SSQHC 1136_ GEGSQ 1141_ LVAAD 1146_ HRGGL 1151_ DGWEQ 1156_PGAGQ
1: Monovalent cation-selective ion channel activated by intracellular Ca(2+) in a voltage- and temperature-dependent manner (PubMed:14634208). Mediates the transport of Na(+), K(+) and Cs(+) ions equally well (PubMed:14634208). Activated directly by increase in intracellular Ca(2+), but is impermeable to it (PubMed:14634208). The activation mechanism of TRPM5 involves a multistep process. TRPM5 activation involves ligand binding (i.e., tastant molecule, glucose stimulation) to Gq/G-protein coupled receptors (GPCR) and leads to the breakdown of phosphatidylinositol bisphosphate (PIP2) into diacylglycerol (DAG) and inositol trisphosphate (IP3), IP3 binds to its receptors in the endoplasmic reticulum and cause calcium release. Simultaneously with the intracellular Ca(2+) release, DAG activates the protein kinase C (PKC), which phosphorylates the TRPM5 channel. This phosphorylation combined with the bound Ca(2+), leads to a robust inward current allowing the entry of sodium ions (Na+) into the cell. This ion influx depolarizes the cell membrane, generating action potentials that propagate TRPM5 signals. Is a key player in sensing sweet, umami and bitter stimuli (By similarity). Involved in insulin secretion by pancreatic beta cells (By similarity)