Killer cell lectin-like receptor subfamily F member 1 (Lectin-like receptor F1) (Activating coreceptor NKp80) (C-type lectin domain family 5 member C)
1_MQDEE 6_ RYMTL 11_ NVQSK 16_ KRSSA 21_ QTSQL 26_ TFKDY 31_ SVTLH 36_ WYKIL 41_ LGISG 46_ TVNGI 51_ LTLTL 56_ ISLIL 61_ LVSQG 66_ VLLKC 71_ QKGSC 76_ SNATQ 81_ YEDTG 86_ DLKVN 91_ NGTRR 96_ NISNK 101_ DLCAS 106_ RSADQ 111_ TVLCQ 116_ SEWLK 121_ YQGKC 126_ YWFSN 131_ EMKSW 136_ SDSYV 141_ YCLER 146_ KSHLL 151_ IIHDQ 156_ LEMAF 161_ IQKNL 166_ RQLNY 171_ VWIGL 176_ NFTSL 181_ KMTWT 186_ WVDGS 191_ PIDSK 196_ IFFIK 201_ GPAKE 206_ NSCAA 211_ IKESK 216_ IFSET 221_ CSSVF 226_KWICQ
1: Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases (PubMed:21149606)