Bifunctional apoptosis regulator (RING finger protein 47)
1_MEEPQ 6_ KSYVN 11_ TMDLE 16_ RDEPL 21_ KSTGP 26_ QISVS 31_ EFSCH 36_ CCYDI 41_ LVNPT 46_ TLNCG 51_ HSFCR 56_ HCLAL 61_ WWASS 66_ KKTEC 71_ PECRE 76_ KWEGF 81_ PKVSI 86_ LLRDA 91_ IEKLF 96_ PDAIR 101_ LRFED 106_ IQQNN 111_ DIVQS 116_ LAAFQ 121_ KYGND 126_ QIPLA 131_ PNTGR 136_ ANQQM 141_ GGGFF 146_ SGVLT 151_ ALTGV 156_ AVVLL 161_ VYHWS 166_ SRESE 171_ HDLLV 176_ HKAVA 181_ KWTAE 186_ EVVLW 191_ LEQLG 196_ PWASL 201_ YRERF 206_ LSERV 211_ NGRLL 216_ LTLTE 221_ EEFSK 226_ TPYTI 231_ ENSSH 236_ RRAIL 241_ MELER 246_ VKALG 251_ VKPPQ 256_ NLWEY 261_ KAVNP 266_ GRSLF 271_ LLYAL 276_ KSSPR 281_ LSLLY 286_ LYLFD 291_ YTDTF 296_ LPFIH 301_ TICPL 306_ QEDSS 311_ GEDIV 316_ TKLLD 321_ LKEPT 326_ WKQWR 331_ EFLVK 336_ YSFLP 341_ YQLIA 346_ EFAWD 351_ WLEVH 356_ YWTSR 361_ FLIIN 366_ AMLLS 371_ VLELF 376_ SFWRI 381_ WSRSE 386_ LKTVP 391_ QRMWS 396_ HFWKV 401_ STQGL 406_ FVAMF 411_ WPLIP 416_ QFVCN 421_ CLFYW 426_ ALYFN 431_ PIINI 436_ DLVVK 441_ELRRL
1: Membrane-bound E3 ubiquitin ligase that plays a role in several processes including apoptosis regulation or reticulum endoplasmic stress (PubMed:14502241, PubMed:21068390). Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (PubMed:14502241). Contributes to the dynamic control of IRE1/ERN1 signaling during ER stress by inducing BAX inhibitor 1/TMBIM6 proteasomal degradation (PubMed:21068390). Promotes the activation of TGF-beta signaling by mediating the 'Lys-63'-linked ubiquitination of TGFBR1 which is critical to activate the pathway (PubMed:33914044). Together with NGFR, negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed:22566094). Promotes the proteasome-mediated degradation of PNPLA3, a protein involveld in lipid metabolism (PubMed:38294943)