Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3)
1_MISAA 6_ WSIFL 11_ IGTKI 16_ GLFLQ 21_ VAPLS 26_ VMAKS 31_ CPSVC 36_ RCDAG 41_ FIYCN 46_ DRFLT 51_ SIPTG 56_ IPEDA 61_ TTLYL 66_ QNNQI 71_ NNAGI 76_ PSDLK 81_ NLLKV 86_ ERIYL 91_ YHNSL 96_ DEFPT 101_ NLPKY 106_ VKELH 111_ LQENN 116_ IRTIT 121_ YDSLS 126_ KIPYL 131_ EELHL 136_ DDNSV 141_ SAVSI 146_ EEGAF 151_ RDSNY 156_ LRLLF 161_ LSRNH 166_ LSTIP 171_ WGLPR 176_ TIEEL 181_ RLDDN 186_ RISTI 191_ SSPSL 196_ QGLTS 201_ LKRLV 206_ LDGNL 211_ LNNHG 216_ LGDKV 221_ FFNLV 226_ NLTEL 231_ SLVRN 236_ SLTAA 241_ PVNLP 246_ GTNLR 251_ KLYLQ 256_ DNHIN 261_ RVPPN 266_ AFSYL 271_ RQLYR 276_ LDMSN 281_ NNLSN 286_ LPQGI 291_ FDDLD 296_ NITQL 301_ ILRNN 306_ PWYCG 311_ CKMKW 316_ VRDWL 321_ QSLPV 326_ KVNVR 331_ GLMCQ 336_ APEKV 341_ RGMAI 346_ KDLNA 351_ ELFDC 356_ KDSGI 361_ VSTIQ 366_ ITTAI 371_ PNTVY 376_ PAQGQ 381_ WPAPV 386_ TKQPD 391_ IKNPK 396_ LTKDH 401_ QTTGS 406_ PSRKT 411_ ITITV 416_ KSVTS 421_ DTIHI 426_ SWKLA 431_ LPMTA 436_ LRLSW 441_ LKLGH 446_ SPAFG 451_ SITET 456_ IVTGE 461_ RSEYL 466_ VTALE 471_ PDSPY 476_ KVCMV 481_ PMETS 486_ NLYLF 491_ DETPV 496_ CIETE 501_ TAPLR 506_ MYNPT 511_ TTLNR 516_ EQEKE 521_ PYKNP 526_ NLPLA 531_ AIIGG 536_ AVALV 541_ TIALL 546_ ALVCW 551_ YVHRN 556_ GSLFS 561_ RNCAY 566_ SKGRR 571_ RKDDY 576_ AEAGT 581_ KKDNS 586_ ILEIR 591_ ETSFQ 596_ MLPIS 601_ NEPIS 606_ KEEFV 611_ IHTIF 616_ PPNGM 621_ NLYKN 626_ NHSES 631_ SSNRS 636_ YRDSG 641_IPDSD
1: Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity)