LIM and cysteine-rich domains protein 1 (Dyxin)
1_MAKVA 6_ KDLNP 11_ GVKKM 16_ SLGQL 21_ QSARG 26_ VACLG 31_ CKGTC 36_ SGFEP 41_ HSWRK 46_ ICKSC 51_ KCSQE 56_ DHCLT 61_ SDLED 66_ DRKIG 71_ RLLMD 76_ SKYST 81_ LTARV 86_ KGGDG 91_ IRIYK 96_ RNRMI 101_ MTNPI 106_ ATGKD 111_ PTFDT 116_ ITYEW 121_ APPGV 126_ TQKLG 131_ LQYME 136_ LIPKE 141_ KQPVT 146_ GTEGA 151_ FYRRR 156_ QLMHQ 161_ LPIYD 166_ QDPSR 171_ CRGLL 176_ ENELK 181_ LMEEF 186_ VKQYK 191_ SEALG 196_ VGEVA 201_ LPGQG 206_ GLPKE 211_ EGKQQ 216_ EKPEG 221_ AETTA 226_ ATTNG 231_ SLSDP 236_ SKEVE 241_ YVCEL 246_ CKGAA 251_ PPDSP 256_ VVYSD 261_ RAGYN 266_ KQWHP 271_ TCFVC 276_ AKCSE 281_ PLVDL 286_ IYFWK 291_ DGAPW 296_ CGRHY 301_ CESLR 306_ PRCSG 311_ CDEII 316_ FAEDY 321_ QRVED 326_ LAWHR 331_ KHFVC 336_ EGCEQ 341_ LLSGR 346_ AYIVT 351_ KGQLL 356_CPTCS
1: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway