Selenoprotein N (SelN)
1_MGRAR 6_ PGQRG 11_ PPSPG 16_ PAAQP 21_ PAPPR 26_ RRARS 31_ LALLG 36_ ALLAA 41_ AAAAA 46_ VRVCA 51_ RHAEA 56_ QAAAR 61_ QELAL 66_ KTLGT 71_ DGLFL 76_ FSSLD 81_ TDGDM 86_ YISPE 91_ EFKPI 96_ AEKLT 101_ GSCSV 106_ TQTGV 111_ QWCSH 116_ SSLQP 121_ QLPWL 126_ NUSSC 131_ LSLLR 136_ STPAA 141_ SCEEE 146_ ELPPD 151_ PSEET 156_ LTIEA 161_ RFQPL 166_ LPETM 171_ TKSKD 176_ GFLGV 181_ SRLAL 186_ SGLRN 191_ WTAAA 196_ SPSAV 201_ FATRH 206_ FQPFL 211_ PPPGQ 216_ ELGEP 221_ WWIIP 226_ SELSM 231_ FTGYL 236_ SNNRF 241_ YPPPP 246_ KGKEV 251_ IIHRL 256_ LSMFH 261_ PRPFV 266_ KTRFA 271_ PQGAV 276_ ACLTA 281_ ISDFY 286_ YTVMF 291_ RIHAE 296_ FQLSE 301_ PPDFP 306_ FWFSP 311_ AQFTG 316_ HIILS 321_ KDATH 326_ VRDFR 331_ LFVPN 336_ HRSLN 341_ VDMEW 346_ LYGAS 351_ ESSNM 356_ EVDIG 361_ YIPQM 366_ ELEAT 371_ GPSVP 376_ SVILD 381_ EDGSM 386_ IDSHL 391_ PSGEP 396_ LQFVF 401_ EEIKW 406_ QQELS 411_ WEEAA 416_ RRLEV 421_ AMYPF 426_ KKVSY 431_ LPFTE 436_ AFDRA 441_ KAENK 446_ LVHSI 451_ LLWGA 456_ LDDQS 461_ CUGSG 466_ RTLRE 471_ TVLES 476_ SPILT 481_ LLNES 486_ FISTW 491_ SLVKE 496_ LEELQ 501_ NNQEN 506_ SSHQK 511_ LAGLH 516_ LEKYS 521_ FPVEM 526_ MICLP 531_ NGTVV 536_ HHINA 541_ NYFLD 546_ ITSVK 551_ PEEIE 556_ SNLFS 561_ FSSTF 566_ EDPST 571_ ATYMQ 576_ FLKEG 581_LRRGL
1: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:18713863, PubMed:19557870)
2: Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290)