Methionine-R-sulfoxide reductase B1 (MsrB1) (EC 1.8.4.12) (EC 1.8.4.14) (Selenoprotein X) (SelX)
1_MSFCS 6_ FFGGE 11_ VFQNH 16_ FEPGV 21_ YVCAK 26_ CGYEL 31_ FSSRS 36_ KYAHS 41_ SPWPA 46_ FTETI 51_ HADSV 56_ AKRPE 61_ HNRSE 66_ ALKVS 71_ CGKCG 76_ NGLGH 81_ EFLND 86_ GPKPG 91_ QSRFU 96_ IFSSS 101_ LKFVP 106_ KGKET 111_SASQG
1: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages