Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60)
1_MNRLF 6_ GKAKP 11_ KAPPP 16_ SLTDC 21_ IGTVD 26_ SRAES 31_ IDKKI 36_ SRLDA 41_ ELVKY 46_ KDQIK 51_ KMREG 56_ PAKNM 61_ VKQKA 66_ LRVLK 71_ QKRMY 76_ EQQRD 81_ NLAQQ 86_ SFNME 91_ QANYT 96_ IQSLK 101_ DTKTT 106_ VDAMK 111_ LGVKE 116_ MKKAY 121_ KQVKI 126_ DQIED 131_ LQDQL 136_ EDMME 141_ DANEI 146_ QEALS 151_ RSYGT 156_ PELDE 161_ DDLEA 166_ ELDAL 171_ GDELL 176_ ADEDS 181_ SYLDE 186_ AASAP 191_ AIPEG 196_ VPTDT 201_ KNKDG 206_ VLVDE 211_FGLPQ
1: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses) (PubMed:14519844). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release (PubMed:14519844)