COMM domain-containing protein 9
1_MAALT 6_ AEHFA 11_ ALQSL 16_ LKASS 21_ KDVVR 26_ QLCQE 31_ SFSSS 36_ ALGLK 41_ KLLDV 46_ TCSSL 51_ SVTQE 56_ EAEEL 61_ LQALH 66_ RLTRL 71_ VAFRD 76_ LSSAE 81_ AILAL 86_ FPENF 91_ HQNLK 96_ NLLTK 101_ IILEH 106_ VSTWR 111_ TEAQA 116_ NQISL 121_ PRLVD 126_ LDWRV 131_ DIKTS 136_ SDSIS 141_ RMAVP 146_ TCLLQ 151_ MKIQE 156_ DPSLC 161_ GDKPS 166_ ISAVT 171_ VELSK 176_ ETLDT 181_ MLDGL 186_ GRIRD 191_QLSAV
1: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203)