Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 3) (HACD3) (Butyrate-induced protein 1) (B-ind1) (hB-ind1) (Protein-tyrosine phosphatase-like A domain-containing protein 1)
1_MENQV 6_ LTPHV 11_ YWAQR 16_ HRELY 21_ LRVEL 26_ SDVQN 31_ PAISI 36_ TENVL 41_ HFKAQ 46_ GHGAK 51_ GDNVY 56_ EFHLE 61_ FLDLV 66_ KPEPV 71_ YKLTQ 76_ RQVNI 81_ TVQKK 86_ VSQWW 91_ ERLTK 96_ QEKRP 101_ LFLAP 106_ DFDRW 111_ LDESD 116_ AEMEL 121_ RAKEE 126_ ERLNK 131_ LRLES 136_ EGSPE 141_ TLTNL 146_ RKGYL 151_ FMYNL 156_ VQFLG 161_ FSWIF 166_ VNLTV 171_ RFCIL 176_ GKESF 181_ YDTFH 186_ TVADM 191_ MYFCQ 196_ MLAVV 201_ ETINA 206_ AIGVT 211_ TSPVL 216_ PSLIQ 221_ LLGRN 226_ FILFI 231_ IFGTM 236_ EEMQN 241_ KAVVF 246_ FVFYL 251_ WSAIE 256_ IFRYS 261_ FYMLT 266_ CIDMD 271_ WKVLT 276_ WLRYT 281_ LWIPL 286_ YPLGC 291_ LAEAV 296_ SVIQS 301_ IPIFN 306_ ETGRF 311_ SFTLP 316_ YPVKI 321_ KVRFS 326_ FFLQI 331_ YLIMI 336_ FLGLY 341_ INFRH 346_ LYKQR 351_ RRRYG 356_QKKKK
1: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571)