Mediator of RNA polymerase II transcription subunit 11 (Mediator complex subunit 11)
1_MATYS 6_ LANER 11_ LRALE 16_ DIERE 21_ IGAIL 26_ QNAGT 31_ VILEL 36_ SKEKT 41_ NERLL 46_ DRQAA 51_ AFTAS 56_ VQHVE 61_ AELSA 66_ QIRYL 71_ TQVAT 76_ GQPHE 81_ GSSYS 86_ SRKDC 91_ QMALK 96_ RVDYA 101_ RLKLS 106_ DVART 111_CEQML
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for theee assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors