NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Cell death regulatory protein GRIM-19) (Complex I-B16.6) (CI-B16.6) (Gene associated with retinoic and interferon-induced mortality 19 protein) (GRIM-19) (Gene associated with retinoic and IFN-induced mortality 19 protein) (NADH-ubiquinone oxidoreductase B16.6 subunit)
1_MAASK 6_ VKQDM 11_ PPPGG 16_ YGPID 21_ YKRNL 26_ PRRGL 31_ SGYSM 36_ LAIGI 41_ GTLIY 46_ GHWSI 51_ MKWNR 56_ ERRRL 61_ QIEDF 66_ EARIA 71_ LLPLL 76_ QAETD 81_ RRTLQ 86_ MLREN 91_ LEEEA 96_ IIMKD 101_ VPDWK 106_ VGESV 111_ FHTTR 116_ WVPPL 121_ IGELY 126_ GLRTT 131_ EEALH 136_ASHGF
1: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091)