E3 ubiquitin-protein ligase KCMF1 (EC 2.3.2.27) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (RING-type E3 ubiquitin transferase KCMF1) (ZZ-type zinc finger-containing protein 1)
1_MSRHE 6_ GVSCD 11_ ACLKG 16_ NFRGR 21_ RYKCL 26_ ICYDY 31_ DLCAS 36_ CYESG 41_ ATTTR 46_ HTTDH 51_ PMQCI 56_ LTRVD 61_ FDLYY 66_ GGEAF 71_ SVEQP 76_ QSFTC 81_ PYCGK 86_ MGYTE 91_ TSLQE 96_ HVTSE 101_ HAETS 106_ TEVIC 111_ PICAA 116_ LPGGD 121_ PNHVT 126_ DDFAA 131_ HLTLE 136_ HRAPR 141_ DLDES 146_ SGVRH 151_ VRRMF 156_ HPGRG 161_ LGGPR 166_ ARRSN 171_ MHFTS 176_ SSTGG 181_ LSSSQ 186_ SSYSP 191_ SNREA 196_ MDPIA 201_ ELLSQ 206_ LSGVR 211_ RSAGG 216_ QLNSS 221_ GPSAS 226_ QLQQL 231_ QMQLQ 236_ LERQH 241_ AQAAR 246_ QQLET 251_ ARNAT 256_ RRTNT 261_ SSVTT 266_ TITQS 271_ TATTN 276_ IANTE 281_ SSQQT 286_ LQNSQ 291_ FLLTR 296_ LNDPK 301_ MSETE 306_ RQSME 311_ SERAD 316_ RSLFV 321_ QELLL 326_ STLVR 331_ EESSS 336_ SDEDD 341_ RGEMA 346_ DFGAM 351_ GCVDI 356_ MPLDV 361_ ALENL 366_ NLKES 371_ NKGNE 376_PPPPP
1: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (PubMed:15581609, PubMed:25582440, PubMed:34893540, PubMed:37891180, PubMed:38297121). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (PubMed:34893540, PubMed:37891180). Does not ubiquitinate proteins that are acetylated at the N-terminus (PubMed:37891180). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (PubMed:34893540). Catalytic component of the SIFI complex, a multiprotein complex required to inhibit the mitochondrial stress response after a specific stress event has been resolved: ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121)