Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33)
1_MASAS 6_ GAMAK 11_ HEQIL 16_ VLDPP 21_ TDLKF 26_ KGPFT 31_ DVVTT 36_ NLKLR 41_ NPSDR 46_ KVCFK 51_ VKTTA 56_ PRRYC 61_ VRPNS 66_ GIIDP 71_ GSTVT 76_ VSVML 81_ QPFDY 86_ DPNEK 91_ SKHKF 96_ MVQTI 101_ FAPPN 106_ TSDME 111_ AVWKE 116_ AKPDE 121_ LMDSK 126_ LRCVF 131_ EMPNE 136_ NDKLN 141_ DMEPS 146_ KAVPL 151_ NASKQ 156_ DGPMP 161_ KPHSV 166_ SLNDT 171_ ETRKL 176_ MEECK 181_ RLQGE 186_ MMKLS 191_ EENRH 196_ LRDEG 201_ LRLRK 206_ VAHSD 211_ KPGST 216_ STASF 221_ RDNVT 226_ SPLPS 231_ LLVVI 236_ AAIFI 241_GFFLG
1: Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470)