Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)
1_MSART 6_ PLPTV 11_ NERDT 16_ ENHTS 21_ VDGYT 26_ EPHIQ 31_ PTKSS 36_ SRQNI 41_ PRCRN 46_ SITSA 51_ TDEQP 56_ HIGNY 61_ RLQKT 66_ IGKGN 71_ FAKVK 76_ LARHV 81_ LTGRE 86_ VAVKI 91_ IDKTQ 96_ LNPTS 101_ LQKLF 106_ REVRI 111_ MKILN 116_ HPNIV 121_ KLFEV 126_ IETEK 131_ TLYLV 136_ MEYAS 141_ GGEVF 146_ DYLVA 151_ HGRMK 156_ EKEAR 161_ AKFRQ 166_ IVSAV 171_ QYCHQ 176_ KYIVH 181_ RDLKA 186_ ENLLL 191_ DGDMN 196_ IKIAD 201_ FGFSN 206_ EFTVG 211_ NKLDT 216_ FCGSP 221_ PYAAP 226_ ELFQG 231_ KKYDG 236_ PEVDV 241_ WSLGV 246_ ILYTL 251_ VSGSL 256_ PFDGQ 261_ NLKEL 266_ RERVL 271_ RGKYR 276_ IPFYM 281_ STDCE 286_ NLLKK 291_ LLVLN 296_ PIKRG 301_ SLEQI 306_ MKDRW 311_ MNVGH 316_ EEEEL 321_ KPYTE 326_ PDPDF 331_ NDTKR 336_ IDIMV 341_ TMGFA 346_ RDEIN 351_ DALIN 356_ QKYDE 361_ VMATY 366_ ILLGR 371_ KPPEF 376_ EGGES 381_ LSSGN 386_ LCQRS 391_ RPSSD 396_ LNNST 401_ LQSPA 406_ HLKVQ 411_ RSISA 416_ NQKQR 421_ RFSDH 426_ AGPSI 431_ PPAVS 436_ YTKRP 441_ QANSV 446_ ESEQK 451_ EEWDK 456_ DVARK 461_ LGSTT 466_ VGSKS 471_ EMTAS 476_ PLVGP 481_ ERKKS 486_ STIPS 491_ NNVYS 496_ GGSMA 501_ RRNTY 506_ VCERT 511_ TDRYV 516_ ALQNG 521_ KDSSL 526_ TEMSV 531_ SSISS 536_ AGSSV 541_ ASAVP 546_ SARPR 551_ HQKSM 556_ STSGH 561_ PIKVT 566_ LPTIK 571_ DGSEA 576_ YRPGT 581_ TQRVP 586_ AASPS 591_ AHSIS 596_ TATPD 601_ RTRFP 606_ RGSSS 611_ RSTFH 616_ GEQLR 621_ ERRSV 626_ AYNGP 631_ PASPS 636_ HETGA 641_ FAHAR 646_ RGTST 651_ GIISK 656_ ITSKF 661_ VRRDP 666_ SEGEA 671_ SGRTD 676_ TSRST 681_ SGEPK 686_ ERDKE 691_ EGKDS 696_ KPRSL 701_ RFTWS 706_ MKTTS 711_ SMDPN 716_ DMMRE 721_ IRKVL 726_ DANNC 731_ DYEQK 736_ ERFLL 741_ FCVHG 746_ DARQD 751_ SLVQW 756_ EMEVC 761_ KLPRL 766_ SLNGV 771_ RFKRI 776_ SGTSI 781_ AFKNI 786_ASKIA
1: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3)