Interleukin-17C (IL-17C) (Cytokine CX2)
1_MTLLP 6_ GLLFL 11_ TWLHT 16_ CLAHH 21_ DPSLR 26_ GHPHS 31_ HGTPH 36_ CYSAE 41_ ELPLG 46_ QAPPH 51_ LLARG 56_ AKWGQ 61_ ALPVA 66_ LVSSL 71_ EAASH 76_ RGRHE 81_ RPSAT 86_ TQCPV 91_ LRPEE 96_ VLEAD 101_ THQRS 106_ ISPWR 111_ YRVDT 116_ DEDRY 121_ PQKLA 126_ FAECL 131_ CRGCI 136_ DARTG 141_ RETAA 146_ LNSVR 151_ LLQSL 156_ LVLRR 161_ RPCSR 166_ DGSGL 171_ PTPGA 176_ FAFHT 181_ EFIHV 186_ PVGCT 191_CVLPR
1: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases