Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)
1_MSGRS 6_ GKKKM 11_ SKLSR 16_ SARAG 21_ VIFPV 26_ GRLMR 31_ YLKKG 36_ TFKYR 41_ ISVGA 46_ PVYMA 51_ AVIEY 56_ LAAEI 61_ LELAG 66_ NAARD 71_ NKKAR 76_ IAPRH 81_ ILLAV 86_ ANDEE 91_ LNQLL 96_ KGVTI 101_ ASGGV 106_ LPRIH 111_ PELLA 116_ KKRGT 121_ KGKSE 126_ TILSP 131_ PPEKR 136_ GRKAT 141_ SGKKG 146_ GKKSK 151_ AAKPR 156_ TSKKS 161_ KPKDS 166_ DKEGT 171_ SNSTS 176_ EDGPG 181_ DGFTI 186_ LSSKS 191_ LVLGQ 196_ KLSLT 201_ QSDIS 206_ HIGSM 211_ RVEGI 216_ VHPTT 221_ AEIDL 226_ KEDIG 231_ KALEK 236_ AGGKE 241_ FLETV 246_ KELRK 251_ SQGPL 256_ EVAEA 261_ AVSQS 266_ SGLAA 271_ KFVIH 276_ CHIPQ 281_ WGSDK 286_ CEEQL 291_ EETIK 296_ NCLSA 301_ AEDKK 306_ LKSVA 311_ FPPFP 316_ SGRNC 321_ FPKQT 326_ AAQVT 331_ LKAIS 336_ AHFDD 341_ SSASS 346_ LKNVY 351_ FLLFD 356_ SESIG 361_ IYVQE 366_MAKLD
1: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation