TBC1 domain family member 7 (Cell migration-inducing protein 23)
1_MTEDS 6_ QRNFR 11_ SVYYE 16_ KVGFR 21_ GVEEK 26_ KSLEI 31_ LLKDD 36_ RLDTE 41_ KLCTF 46_ SQRFP 51_ LPSMY 56_ RALVW 61_ KVLLG 66_ ILPPH 71_ HESHA 76_ KVMMY 81_ RKEQY 86_ LDVLH 91_ ALKVV 96_ RFVSD 101_ ATPQA 106_ EVYLR 111_ MYQLE 116_ SGKLP 121_ RSPSF 126_ PLEPD 131_ DEVFL 136_ AIAKA 141_ MEEMV 146_ EDSVD 151_ CYWIT 156_ RRFVN 161_ QLNTK 166_ YRDSL 171_ PQLPK 176_ AFEQY 181_ LNLED 186_ GRLLT 191_ HLRMC 196_ SAAPK 201_ LPYDL 206_ WFKRC 211_ FAGCL 216_ PESSL 221_ QRVWD 226_ KVVSG 231_ SCKIL 236_ VFVAV 241_ EILLT 246_ FKIKV 251_ MALNS 256_ AEKIT 261_ KFLEN 266_ IPQDS 271_ SDAIV 276_ SKAID 281_ LWHKH 286_CGTPV
1: Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:22795129, PubMed:24529379). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:22795129, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:22795129). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:24529379)