Mitochondrial transcription rescue factor 1
1_MAMAS 6_ VKLLA 11_ GVLRK 16_ PDAWI 21_ GLWGV 26_ LRGTP 31_ SSYKL 36_ CTSWN 41_ RYLYF 46_ SSTKL 51_ RAPNY 56_ KTLFY 61_ NIFSL 66_ RLPGL 71_ LLSPE 76_ CIFPF 81_ SVRLK 86_ SNIRS 91_ TKSTK 96_ KSLQK 101_ VDEED 106_ SDEES 111_ HHDEM 116_ SEQEE 121_ ELEDD 126_ PTVVK 131_ NYKDL 136_ EKAVQ 141_ SFRYD 146_ VVLKT 151_ GLDIG 156_ RNKVE 161_ DAFYK 166_ GELRL 171_ NEEKL 176_ WKKSR 181_ TVKVG 186_ DTLDL 191_ LIGED 196_ KEAGT 201_ ETVMR 206_ ILLKK 211_ VFEEK 216_ TESEK 221_ YRVVL 226_ RRWKS 231_LKLPK
1: Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability (PubMed:31226201). Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed:31396629, PubMed:33243891). As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed:33243891)