GSK3B-interacting protein (GSKIP) (GSK3beta interaction protein)
1_METDC 6_ NPMEL 11_ SSMSG 16_ FEEGS 21_ ELNGF 26_ EGTDM 31_ KDMRL 36_ EAEAV 41_ VNDVL 46_ FAVNN 51_ MFVSK 56_ SLRCA 61_ DDVAY 66_ INVET 71_ KERNR 76_ YCLEL 81_ TEAGL 86_ KVVGY 91_ AFDQV 96_ DDHLQ 101_ TPYHE 106_ TVYSL 111_ LDTLS 116_ PAYRE 121_ AFGNA 126_ LLQRL 131_EALKR
1: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:16981698, PubMed:25920809, PubMed:27484798). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:16981698, PubMed:27484798). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702)