Gene name: COX16

Uniprot entry:

Q9P0S2

Protein names:

Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial (hCOX16)

Protein sequence:

1_MFAPA 6_ VMRAF 11_ RKNKT 16_ LGYGV 21_ PMLLL 26_ IVGGS 31_ FGLRE 36_ FSQIR 41_ YDAVK 46_ SKMDP 51_ ELEKK 56_ LKENK 61_ ISLES 66_ EYEKI 71_ KDSKF 76_ DDWKN 81_ IRGPR 86_ PWEDP 91_ DLLQG 96_ RNPES 101_LKTKT

Protein annotations

Protein functions:

1: Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:29355485, PubMed:29381136, PubMed:33169484). Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (PubMed:29355485, PubMed:29381136). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6 (PubMed:29381136). Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines (PubMed:29381136)