Gene name: ORMDL1

Uniprot entry:

Q9P0S3

Protein names:

ORM1-like protein 1 (Adoplin-1)

Protein sequence:

1_MNVGV 6_ AHSEV 11_ NPNTR 16_ VMNSR 21_ GMWLT 26_ YALGV 31_ GLLHI 36_ VLLSI 41_ PFFSV 46_ PVAWT 51_ LTNII 56_ HNLGM 61_ YVFLH 66_ AVKGT 71_ PFETP 76_ DQGKA 81_ RLLTH 86_ WEQLD 91_ YGVQF 96_ TSSRK 101_ FFTIS 106_ PIILY 111_ FLASF 116_ YTKYD 121_ PTHFI 126_ LNTAS 131_ LLSVL 136_ IPKMP 141_ QLHGV 146_RIFGI

Protein annotations

Protein functions:

1: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:20182505). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity)