Proton-transporting V-type ATPase complex assembly regulator TMEM9 (v-ATPase assembly regulator TMEM9) (Dermal papilla-derived protein 4) (Transmembrane protein 9) (Protein TMEM9)
1_MKLLS 6_ LVAVV 11_ GCLLV 16_ PPAEA 21_ NKSSE 26_ DIRCK 31_ CICPP 36_ YRNIS 41_ GHIYN 46_ QNVSQ 51_ KDCNC 56_ LHVVE 61_ PMPVP 66_ GHDVE 71_ AYCLL 76_ CECRY 81_ EERST 86_ TTIKV 91_ IIVIY 96_ LSVVG 101_ ALLLY 106_ MAFLM 111_ LVDPL 116_ IRKPD 121_ AYTEQ 126_ LHNEE 131_ ENEDA 136_ RSMAA 141_ AAASL 146_ GGPRA 151_ NTVLE 156_ RVEGA 161_ QQRWK 166_ LQVQE 171_ QRKTV 176_FDRHK
1: Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (PubMed:30374053). By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation (PubMed:30374053). TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC (PubMed:30374053, PubMed:32380568). In the liver, involved in hepatic regeneration (PubMed:32380568)