Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1)
1_MDDIA 6_ DRMRM 11_ DAGEV 16_ TLVNH 21_ NSVFK 26_ THLLP 31_ QTGFP 36_ EDQLS 41_ LSDQQ 46_ ILSSR 51_ QGHLD 56_ RSFTC 61_ STRSA 66_ AYNPS 71_ YYSDN 76_ PSSDS 81_ FLGSG 86_ DLRTF 91_ GQSAN 96_ GQWRN 101_ STPSS 106_ SSSLQ 111_ KSRNS 116_ RSLYL 121_ ETRKT 126_ SSGLS 131_ NSFAG 136_ KSNHH 141_ CHVSA 146_ YEKSF 151_ PIKPV 156_ PSPSW 161_ SGSCR 166_ RSLLS 171_ PKKTQ 176_ RRHVS 181_ TAEET 186_ VQEEE 191_ REIYR 196_ QLLQM 201_ VTGKQ 206_ FTIAK 211_ PTTHF 216_ PLHLS 221_ RCLSS 226_ SKNTL 231_ KDSLF 236_ KNGNS 241_ CASQI 246_ IGSDT 251_ SSSGS 256_ ASILT 261_ NQEQL 266_ SHSVY 271_ SLSSY 276_ TPDVA 281_ FGSKD 286_ SGTLH 291_ HPHHH 296_ HSVPH 301_ QPDNL 306_ AASNT 311_ QSEGS 316_ DSVIL 321_ LKVKD 326_ SQTPT 331_ PSSTF 336_ FQAEL 341_ WIKEL 346_ TSVYD 351_ SRARE 356_ RLRQI 361_ EEQKA 366_ LALQL 371_ QNQRL 376_ QEREH 381_ SVHDS 386_ VELHL 391_ RVPLE 396_ KEIPV 401_ TVVQE 406_ TQKKG 411_ HKLTD 416_ SEDEF 421_ PEITE 426_ EMEKE 431_ IKNVF 436_ RNGNQ 441_ DEVLS 446_ EAFRL 451_ TITRK 456_ DIQTL 461_ NHLNW 466_ LNDEI 471_ INFYM 476_ NMLME 481_ RSKEK 486_ GLPSV 491_ HAFNT 496_ FFFTK 501_ LKTAG 506_ YQAVK 511_ RWTKK 516_ VDVFS 521_ VDILL 526_ VPIHL 531_ GVHWC 536_ LAVVD 541_ FRKKN 546_ ITYYD 551_ SMGGI 556_ NNEAC 561_ RILLQ 566_ YLKQE 571_ SIDKK 576_ RKEFD 581_ TNGWQ 586_ LFSKK 591_ SQEIP 596_ QQMNG 601_ SDCGM 606_ FACKY 611_ ADCIT 616_ KDRPI 621_ NFTQQ 626_ HMPYF 631_ RKRMV 636_WEILH
1: Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15199155, PubMed:16253240, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:15199155, PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (PubMed:29506078, PubMed:34048572, PubMed:37257451). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844)