SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein)
1_MAAQR 6_ IRAAN 11_ SNGLP 16_ RCKSE 21_ GTLID 26_ LSEGF 31_ SETSF 36_ NDIKV 41_ PSPSA 46_ LLVDN 51_ PTPFG 56_ NAKEV 61_ IAIKD 66_ YCPTN 71_ FTTLK 76_ FSKGD 81_ HLYVL 86_ DTSGG 91_ EWWYA 96_ HNTTE 101_ MGYIP 106_ SSYVQ 111_ PLNYR 116_ NSTLS 121_ DSGMI 126_ DNLPD 131_ SPDEV 136_ AKELE 141_ LLGGW 146_ TDDKK 151_ VPGRM 156_ YSNNP 161_ FWNGV 166_ QTNPF 171_ LNGNV 176_ PVMPS 181_ LDELN 186_ PKSTV 191_ DLLLF 196_ DAGTS 201_ SFTES 206_ SSATT 211_ NSTGN 216_ IFDEL 221_ PVTNG 226_ LHAEP 231_ PVRRD 236_ NPFFR 241_ SKRSY 246_ SLSEL 251_ SVLQA 256_ KSDAP 261_ TSSSF 266_ FTGLK 271_ SPAPE 276_ QFQSR 281_ EDFRT 286_ AWLNH 291_ RKLAR 296_ SCHDL 301_ DLLGQ 306_ SPGWG 311_ QTQAV 316_ ETNIV 321_ CKLDS 326_ SGGAV 331_ QLPDT 336_ SISIH 341_ VPEGH 346_ VAPGE 351_ TQQIS 356_ MKALL 361_ DPPLE 366_ LNSDR 371_ SCSIS 376_ PVLEV 381_ KLSNL 386_ EVKTS 391_ IILEM 396_ KVSAE 401_ IKNDL 406_ FSKST 411_ VGLQC 416_ LRSDS 421_ KEGPY 426_ VSVPL 431_ NCSCG 436_ DTVQA 441_ QLHNL 446_ EPCMY 451_ VAVVA 456_ HGPSI 461_ LYPST 466_ VWDFI 471_ NKKVT 476_ VGLYG 481_ PKHIH 486_ PSFKT 491_ VVTIF 496_ GHDCA 501_ PKTLL 506_ VSEVT 511_ RQAPN 516_ PAPVA 521_ LQLWG 526_ KHQFV 531_ LSRPQ 536_ DLKVC 541_ MFSNM 546_ TNYEV 551_ KASEQ 556_ AKVVR 561_ GFQLK 566_ LGKVS 571_ RLIFP 576_ ITSQN 581_ PNELS 586_ DFTLR 591_ VQVKD 596_ DQEAI 601_ LTQFC 606_ VQTPQ 611_ PPPKS 616_ AIKPS 621_ GQRRF 626_ LKKNE 631_ VGKII 636_ LSPFA 641_ TTTKY 646_ PTFQD 651_ RPVSS 656_ LKFGK 661_ LLKTV 666_ VRQNK 671_ NHYLL 676_ EYKKG 681_ DGIAL 686_ LSEER 691_ VRLRG 696_ QLWTK 701_ EWYIG 706_ YYQGR 711_ VGLVH 716_ TKNVL 721_ VVGRA 726_ RPSLC 731_ SGPEL 736_ STSVL 741_ LEQIL 746_ RPCKF 751_ LTYIY 756_ ASVRT 761_ LLMEN 766_ ISSWR 771_ SFADA 776_ LGYVN 781_ LPLTF 786_ FCRAE 791_ LDSEP 796_ ERVAS 801_ VLEKL 806_ KEDCN 811_ NTENK 816_ ERKSF 821_ QKELV 826_ MALLK 831_ MDCQG 836_ LVVRL 841_ IQDFV 846_ LLTTA 851_ VEVAQ 856_ RWREL 861_ AEKLA 866_ KVSKQ 871_ QMDAY 876_ ESPHR 881_ DRNGV 886_ VDSEA 891_ MWKPA 896_ YDFLL 901_ TWSHQ 906_ IGDSY 911_ RDVIQ 916_ ELHLG 921_ LDKMK 926_ NPITK 931_ RWKHL 936_ TGTLI 941_ LVNSL 946_ DVLRA 951_ AAFSP 956_ADQDD
1: May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy