Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6)
1_MASNF 6_ NDIVK 11_ QGYVR 16_ IRSRR 21_ LGIYQ 26_ RCWLV 31_ FKKAS 36_ SKGPK 41_ RLEKF 46_ SDERA 51_ AYFRC 56_ YHKVT 61_ ELNNV 66_ KNVAR 71_ LPKST 76_ KKHAI 81_ GIYFN 86_ DDTSK 91_ TFACE 96_ SDLEA 101_ DEWCK 106_ VLQME 111_ CVGTR 116_ INDIS 121_ LGEPD 126_ LLATG 131_ VEREQ 136_ SERFN 141_ VYLMP 146_ SPNLD 151_ VHGEC 156_ ALQIT 161_ YEYIC 166_ LWDVQ 171_ NPRVK 176_ LISWP 181_ LSALR 186_ RYGRD 191_ TTWFT 196_ FEAGR 201_ MCETG 206_ EGLFI 211_ FQTRD 216_ GEAIY 221_ QKVHS 226_ AALAI 231_ AEQHE 236_ RLLQS 241_ VKNSM 246_ LQMKM 251_ SERAA 256_ SLSTM 261_ VPLPR 266_ SAYWQ 271_ HITRQ 276_ HSTGQ 281_ LYRLQ 286_ DVSSP 291_ LKLHR 296_ TETFP 301_AYRSE
1: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation