C-type lectin domain family 1 member B (C-type lectin-like receptor 2) (CLEC-2)
1_MQDED 6_ GYITL 11_ NIKTR 16_ KPALI 21_ SVGSA 26_ SSSWW 31_ RVMAL 36_ ILLIL 41_ CVGMV 46_ VGLVA 51_ LGIWS 56_ VMQRN 61_ YLQGE 66_ NENRT 71_ GTLQQ 76_ LAKRF 81_ CQYVV 86_ KQSEL 91_ KGTFK 96_ GHKCS 101_ PCDTN 106_ WRYYG 111_ DSCYG 116_ FFRHN 121_ LTWEE 126_ SKQYC 131_ TDMNA 136_ TLLKI 141_ DNRNI 146_ VEYIK 151_ ARTHL 156_ IRWVG 161_ LSRQK 166_ SNEVW 171_ KWEDG 176_ SVISE 181_ NMFEF 186_ LEDGK 191_ GNMNC 196_ AYFHN 201_ GKMHP 206_ TFCEN 211_ KHYLM 216_ CERKA 221_GMTKV
1: C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485)
2: (Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485)
3: (Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507)