MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC)
1_MSGAG 6_ EALAP 11_ GPVGP 16_ QRVAE 21_ AGGGQ 26_ LGSTA 31_ QGKCD 36_ KDNTE 41_ KDITQ 46_ ATNSH 51_ FTHGE 56_ MQDQS 61_ IWGNP 66_ SDGEL 71_ IRTQP 76_ QRLPQ 81_ LQTSA 86_ QVPSG 91_ EEIGK 96_ IKNGH 101_ TGLSN 106_ GNGIH 111_ HGAKH 116_ GSADN 121_ RKLSA 126_ PVSQK 131_ MHRKI 136_ QSSLS 141_ VNSDI 146_ SKKSK 151_ VNAVF 156_ SQKTG 161_ SSPED 166_ CCVHC 171_ ILACL 176_ FCEFL 181_ TLCNI 186_ VLGQA 191_ SCGIC 196_ TSEAC 201_ CCCCG 206_ DEMGD 211_ DCNCP 216_ CDMDC 221_ GIMDA 226_ CCESS 231_ DCLEI 236_ CMECC 241_GICFP
1: Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (By similarity). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin (PubMed:12192039). Affects axin regulation of the WNT and JNK signaling pathways (PubMed:12192039). Involved in the development of lymphatic vessel valves (By similarity). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (PubMed:35235341). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348)
2: (Microbial infection) Modulates the expression from viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta (PubMed:12944466, PubMed:16260749, Ref.6). Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR (PubMed:10671520)